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PROTCROWN (Nano Protein Corona Database: A Web-based Repository) was created to provide a collation of protein-nanoparticle interactions, becoming the first web-based Protein Corona database to expand and accelerate the study of protein coronas.
In recent years, the research progress includes the in-depth discussion on the mechanism and influencing factors of protein crown formation. For example, the size, shape and surface chemical properties of nanoparticles, as well as the type, concentration and pH value of proteins, will affect the formation of protein caps.
This database is a tool for data collection, visualization and data retrieval in all experimental studies. In addition, this database realizes certain feature importance analysis and feature extraction of proteins.
(1) Andrea Cappannini, Angana Ray, Elżbieta Purta, Sunandan Mukherjee, Pietro Boccaletto, S NaeimMoafinejad, Antony Lechner, Charles Barchet, Bruno P Klaholz, Filip Stefaniak, Janusz M Bujnicki,MODOMICS: a database of RNA modifications and related information. https://doi.org/10.1093/nar/gkad1083
(2)Chen Cao, Mengting Shao, Chunman Zuo, Devin Kwok, Lin Liu, Yuli Ge, Zilong Zhang, Feifei Cui, Mingshuai Chen, Rui Fan, Yijie Ding, Hangjin Jiang, Guishen Wang, Quan Zou, RAVAR: a curated repository for rare variant–trait associations, Nucleic Acids Research, Volume 52, Issue D1, 5 January 2024, Pages D990–D997, https://doi.org/10.1093/nar/gkad876
(3)Y. Su, S. Yan, C. Cao, F. Cui, Q. Zou and Z. Zhang, "Human-Spa: An Online Platform Based on Spatial Transcriptome Data for Diseases of Human Systems," 2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Istanbul, Turkiye, 2023, pp. 293-298, doi: 10.1109/BIBM58861.2023.10385302.
We have summarized the common questions encountered on the website to provide assistance where needed.
Does the database have functions and instructions?
Our website is dedicated to the comprehensive collection and highly visual presentation of protein corona data. Users can not only smoothly browse and precisely search for the information they need, but also easily download relevant data for further research or analysis. To enhance the user experience, we provide detailed usage tutorials that can be easily accessed in the "TUTORIAL" section.
How complete are the database results and how updated are the data?
Regarding the completeness of database results and data updates, we fully understand the importance of protein corona data integration and are committed to providing strong support to those in need. To this end, we continuously strive to improve the content of our database and regularly update it to ensure data accuracy and timeliness. Users can trust that the data we provide is the latest and most comprehensive.
Whether the download and export functions of data in the database are available?
Users can fully download and export data from the database for use. We provide a "Download" function that allows users to obtain the required data free of charge. These data are saved in a file format suitable for PC, making it easy for users to use in various research or analysis scenarios.
What about security and privacy measures?
In terms of network security and privacy protection, we have taken strict measures. Our website follows internationally recognized best practices and utilizes advanced security technologies to protect user data and information. We have implemented a multi-layer defense strategy, including but not limited to firewall protection, data encryption, regular security audits, and user authentication, to ensure the confidentiality, integrity, and availability of data. Additionally, we strictly comply with relevant laws and regulations to protect user privacy information and will not disclose any personal information without user permission. These measures together form a powerful security protection system, providing users with a safe and trustworthy network environment.